The association between circulating SIGLEC6 and preeclampsia: observational studies of seven cohorts.

ABSTRACT:

Background

Preeclampsia is a serious complication of pregnancy.

Methods

We did an observational study using seven tissue bank/cohorts to examine the association between circulating SIGLEC6 and preeclampsia. We included samples from participants with preterm disease (delivering <34 weeks gestation in Australia), examined whether levels altered with clinical disease severity (samples collected in South Africa) and whether there were alterations preceding disease onset using samples collected at 15- and 20-weeks' gestation in New Zealand, samples collected between 26 and 34 weeks in the UK and samples collected at 28 or 36 weeks gestation in Australia. Circulating SIGLEC6, sFlt-1, and PlGF were measured via ELISA or a electrochemiluminescence immunoassay platform.

Findings</

SUBMITTER: Kaitu'u-Lino TJ 

PROVIDER: S-EPMC12320669 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature