Near-infrared-triggered copper-doped carbon nitride nanocomposite inducing domino effect for synergistic tumor therapy and immune microenvironment reprogramming.

ABSTRACT: Multimodal targeted combination therapies harnessing synergistic interactions have emerged as a transformative paradigm in oncology, gradually superseding conventional monotherapies. We herein report a near-infrared (NIR) light-triggered multifunctional nanocomposite based on copper-doped graphitic-phase carbon nitride (named CNCu@HA), which efficiently eliminates tumors by inducing apoptosis, cuproptosis, and immunogenic cell death (ICD) while initiating robust immune responses. Specifically, the incorporation of copper ions enhances NIR photoabsorption and effectively separates the electron-hole pairs. Moreover, copper ions exhibit Fenton-like reaction capabilities. Consequently, the triggered domino effect of CNCu@HA not only achieves photothermal ablation of tumor cells but also functi

SUBMITTER: Zhang X 

PROVIDER: S-EPMC12320709 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature