Evaluating cardiac function in ex vivo heart perfusion using lumped parameter models.

ABSTRACT:

Background

Heart transplant outcomes and survival depend on the ability to implant well-functioning organs, but there remain no reliable, objective measures of cardiac function prior to implantation. The lack of standardized protocols and advanced technologies results in inconsistencies and subjective assessments, increasing the risk for postoperative graft dysfunction, the leading cause of short-term morbidity and mortality after transplant. Ex-vivo heart perfusion (EVHP) provides a platform to evaluate donor hearts prior to implantation, using machine perfusion to reanimate the heart to a beating, physiologic state. The FDA-approved Organ Care System (OCS) is widely utilized for the evaluation and ex vivo preservation of hearts, particularly from donors after circulatory death (D

SUBMITTER: Roig RC 

PROVIDER: S-EPMC12320713 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature