Psoriasis Patients are Associated with Increased Risk of New-Onset Irritable Bowel Syndrome: A Multicenter, Retrospective Cohort Study.

ABSTRACT: Background: Psoriasis is a chronic systemic inflammatory disease linked to multiple comorbidities. The association between psoriasis and irritable bowel syndrome (IBS) remains insufficiently characterized. Methods: We conducted a retrospective cohort study using the TriNetX US Collaborative Network. Adults with psoriasis (ICD-10-CM L40) diagnosed between 2005 and 2023 were matched 1:1 with non-psoriasis controls based on demographics, socioeconomic status, comorbidities, and healthcare utilization. IBS (ICD-10-CM K58) diagnoses within 90 days of index were excluded. Cox regression models estimated hazard ratios (HRs) with 95% confidence intervals (CIs). Sensitivity analyses varied wash-out periods, follow-up durations, and exposure definitions. Results: After matching

SUBMITTER: Chen SJ 

PROVIDER: S-EPMC12320781 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature