Statins and Pacing-Induced Atrial Myopathy: Unraveling Their Role in Atrioventricular Block Patients with Permanent Pacemakers.

ABSTRACT: Background: Left atrial (LA) myopathy from interventricular dyssynchrony often precedes atrial fibrillation (AF) in atrioventricular block (AVB) patients with frequent right ventricular (RV) pacing, but the role of statin therapy in preventing LA myopathy and associated arrhythmias remains debated. Objectives: This study investigated the mechanisms of LA myopathy and the clinical outcomes of statin therapy in AVB patients with permanent pacemakers (PPMs). Methods: The study comprised an animal, cell, and clinical cohort study. In the animal study, 12 Lanyu miniature pigs were divided into sham control, RV pacing, and RV pacing plus atorvastatin groups to assess cardiac effects over six months. The cellular study used HL-1 atrial myocytes to evaluate fibrosis and protei

SUBMITTER: Lin YS 

PROVIDER: S-EPMC12320783 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature