Pan-cancer single cell transcriptomic clustering reveals heterogeneous CD8⁺ exhausted T cell populations with different immune checkpoint inhibitor responses.

ABSTRACT: In most cancers, T lymphocytes comprise an essential cellular component of the non-neoplastic microenvironment, where they have the capacity to both suppress and support tumor growth. One specialized T lymphocyte population is the CD8⁺ exhausted T cell, which has been intensely studied as an actionable therapeutic target. Unfortunately, there is currently no uniformly accepted classification scheme for these specialized T cells. To provide a potential model for classifying CD8⁺ exhausted T cells, we leveraged single cell transcriptomic analysis of a diverse collection of both human (n = 8) and mouse (n = 4) cancers to identify unique subpopulations shared across tumor types and species. By integrating data from both human and mouse cancer studies, as wel

SUBMITTER: Mu R 

PROVIDER: S-EPMC12320814 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature