Cathelicidin regulates goblet cell mucus secretion and mucus-associated proteins in <i>Citrobacter rodentium</i>-induced colitis.

ABSTRACT: Colonic goblet cells play a crucial role in mucosal defense by secreting Muc2 mucin and other proteins that entrap and expel enteropathogens. However, the role of innate effectors in the gut like cathelicidin peptides in regulating the mucus barrier during infections remains unclear. In this study, we used cathelicidin-deficient (Camp^-/-) littermates, colonoids, and human LS174T goblet-like cells to investigate how cathelicidin modulates goblet cell function and mucosal defense against attaching/effacing enteropathogen Citrobacter rodentium. We showed that increased fecal shedding and epithelial colonization by C. rodentium in Camp^-/- littermates was accompanied by impaired mucus secretion and higher retention of mucin granule

SUBMITTER: Mirzadzare N 

PROVIDER: S-EPMC12320862 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature