ARDS severity in COVID-19: a case-control study of laboratory biomarkers and IL-10 SNP analysis.

ABSTRACT:

Background

Acute respiratory distress syndrome (ARDS), which is often observed in severe cases of coronavirus disease 2019 (COVID-19), is known to be a major contributor to higher mortality rates. This study assesses how hematological parameters, inflammatory biomarkers, cytokines, and the -1,082 A/G polymorphism are associated with ARDS severity in COVID-19 patients.

Methods

Following exclusions, a 6-month prospective case-control study included 82 healthy controls (HCs) and 158 COVID-19 patients with varying severities of ARDS (mild: 73, moderate: 53, and severe: 32). Blood samples were collected at admission, and laboratory biomarkers were assessed using various methods. Statistical analyses included one-way analysis of variance with Tukey's test for group comparisons, Pe

SUBMITTER: Smail SW 

PROVIDER: S-EPMC12320925 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature