Altered epithelial development of the lateral ventricle choroid plexus in Mllt11 mutants.

ABSTRACT: The choroid plexuses (ChPs) are modified epithelial structures that penetrate all four cerebral ventricles and secrete cerebrospinal fluid. They consist of a central stroma that is vascularized with fenestrated blood vessels and connective tissue. The ChPs are of dual embryonic origin, with forebrain neuroepithelial cells contributing to the epithelial component and mesenchymal cells contributing to the stromal cells. The growth of the ChPs into the ventricular spaces is fueled by the migration and proliferation of neuroepithelial progenitor cells originating from the cortical hem. However, the genetic regulation of neuroepithelial progenitor (NEP) migration during ChP development is not well understood. Here, we report the role of Mllt11 (Af1q/Tcf7c) in the formation of the ChP in part by

SUBMITTER: Moore S 

PROVIDER: S-EPMC12320971 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature