LeishTec vaccination disrupts vertical transmission of Leishmania infantum.

ABSTRACT: Zoonotic canine leishmaniosis, caused by Leishmania infantum, is a fatal disease worldwide in both humans and the reservoir host, dogs. The primary route of transmission is via sand fly bite. Vertical, transplacental, transmission of L. infantum to offspring has been shown to be critical for maintenance of infection in both endemic and non-endemic areas. In the United States, canine leishmaniosis (CanL) is enzootic within hunting dog populations. Previous work with US hunting dogs found that transplacental transmission of L. infantum occurs frequently with high infectivity. Dogs born to CanL infected mothers were almost fourteen times more likely to become positive for L. infantum over their lifetime. Globally, public health agencies control CanL through canine and human case detection and

SUBMITTER: Valadares DG 

PROVIDER: S-EPMC12321126 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature