Performance characteristics and potential public health impact of improved pre-erythrocytic malaria vaccines targeting childhood burden.

ABSTRACT: New malaria vaccine development builds on groundbreaking recommendations and roll-out of two approved pre-erythrocytic vaccines (PEVs); RTS,S/AS01 and R21/Matrix-M. Whilst these vaccines are effective in reducing childhood malaria within yearly routine immunization programs or seasonal vaccination, there is little evidence on how different PEV efficacies, durations of protection, and spacing between doses influence the potential to avert uncomplicated and severe childhood malaria. Mainly, lacking understanding of the required vaccine properties and delivery strategies that lead to an effective childhood vaccine with multi-year protection. We used an individual-based model of malaria transmission informed by trial data to quantify trade-offs between PEV performance properties and impact acr

SUBMITTER: Malinga J 

PROVIDER: S-EPMC12321141 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature