Persistence phenotype of adherent-invasive <i>Escherichia coli</i> in response to ciprofloxacin, revealing high-persistence strains.

ABSTRACT: Persister cells are a subpopulation of bacteria capable of surviving antibiotic treatments and are thought to contribute to disease chronicity and symptom relapse of chronic conditions. Crohn's disease (CD) is a multifactorial chronic inflammatory condition of the gastrointestinal tract, and adherent-invasive Escherichia coli (AIEC) have emerged as a key contributor to its pathogenesis. AIEC can survive, replicate, and produce persister cells within macrophages; however, beyond the LF82 reference strain, little is known about the persistence phenotype and its variability among AIEC strains. In this study, the survival of two AIEC reference strains was analyzed following ciprofloxacin treatment, a fluoroquinolone antibiotic commonly used in CD therapy. In addition, four AIEC clinical

SUBMITTER: Perez-Villalobos V 

PROVIDER: S-EPMC12321266 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature