Designing Cyclic Nitrogen-Bridged Sulfonamides with Anti-Cancer Activity.

ABSTRACT: The N-bridgehead heterocyclic structure is an abundant motif in a multitude of natural products. This structural feature is of high interest because it is present in many different bioactive molecules, many of which are well-established pharmaceuticals. The introduction of a sulfone group into the N-bridgehead system yields a new core structure containing a N-bridgehead sulfonamide. While linear sulfonamides can be found in natural products, only artificial cyclic sulfonamides are known to date. Applications of related cyclic sulfonamide compounds include matrix metalloproteinase inhibitors, potential HIV and cancer therapeutics, and anti-inflammatory compounds. To explore the potential bioactivity of the N-bridgehead sulfonamide scaffold, a synthetic route toward these scaffolds is develo

SUBMITTER: Grau BW 

PROVIDER: S-EPMC12321273 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature