Novel 4,5-Dihydrothiazole-Phenylpiperazine Derivatives: Synthesis, Docking Studies and Pharmacological Evaluation as Serotonergic Agents.

ABSTRACT: The synthesis of a new series of long-chain arylpiperazine as serotoninergic ligands (FG 1-18) is described. The combination of structural elements including heterocyclic nucleus, propyl chain, and 4,5-dihydrothiazol-2-ylphenylpiperazines leads to the preparation of different derivatives tested for their affinity toward 5-HT_1A, 5-HT_2A, and 5-HT_2C receptors. The compounds with better affinity and selectivity binding profiles toward 5-HT_1A and 5-HT_2C (FG-1, FG-4, FG-5, FG-6, FG-7, FG-8, and FG-18) are selected for further in vivo assays to determine their functional activity. Finally, to rationalize the obtained results, molecular docking studies are performed. The results of pharmacological studies show that compounds FG-1, FG-5, FG-8,

SUBMITTER: Andreozzi G 

PROVIDER: S-EPMC12321279 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature