Variability and implications of recurrent implantation failure definitions used in the scientific literature: a systematic review.

ABSTRACT:

Study question

How is recurrent implantation failure (RIF) defined in published literature and what is the prognostic agreement of these definitions with recently introduced RIF criteria by ESHRE?

Summary answer

RIF definitions used in current clinical studies are highly variable and only a low proportion of published studies on RIF meet the ESHRE RIF diagnostic threshold.

What is known already

RIF is a key cause of ART failure and growing focus of ART research. However, RIF remains poorly and inconsistently defined in published literature, thereby making the interpretation and clinical applicability of RIF research difficult and highly problematic.

Study design size duration

The electronic databases EMBASE (Ovid), PubMed, Cochrane Central Register Of Controlle

SUBMITTER: Lu JK 

PROVIDER: S-EPMC12321291 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature