Plasmid genomic epidemiology of <i>bla</i> _NDM carbapenemase-producing <i>Enterobacterales</i> in Canada from 2010 to 2023.

ABSTRACT: Carbapenems are broad-spectrum antibiotics that are losing effectiveness against infections caused by multidrug-resistant Enterobacterales that have acquired carbapenemase genes. The New Delhi metallo-β-lactamase (bla _NDM) is one of the most common carbapenemases in Canada and around the globe. These genes are frequently found on conjugative plasmids, which can disseminate through horizontal gene transfer. We applied whole-genome sequencing to characterize 1,032 bla _NDM carbapenemase-producing Enterobacterales isolates collected by the Canadian Nosocomial Infection Surveillance Program from 2010 to 2023. Using a combination of short-read and long-read sequencing, we obtained 226 complete and circular bla _NDM-encodin

SUBMITTER: Lerminiaux N 

PROVIDER: S-EPMC12321488 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature