Feed status and skin injury modulate immunopathology, global gene expression, and survival in channel catfish during virulent <i>Aeromonas hydrophila</i> infection.

ABSTRACT:

Introduction

Virulent Aeromonas hydrophila is a major pathogen in channel catfish (Ictalurus punctatus), that causes motile Aeromonas septicemia and significant economic losses. We investigated the effect of feeding status and skin integrity on the host immune response, disease survival, and gastrointestinal pathology following a vAh challenge.

Methods

Using a bath immersion model, channel catfish were divided into four treatment groups: fin clipped and fed (FCF), fin clipped but not fed (FCN), not fin clipped but fed (NCF), and not fin clipped nor fed (NCN) alongside non-challenged control groups The FCF and NCF groups were fed 2 h prior to the challenge, but the FCN and NCN groups were not. Survival analysis, histopathological assessment, and RNA seque

SUBMITTER: Soku YK 

PROVIDER: S-EPMC12321539 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature