Targeting PDCD4 in cancer and atrial fibrillation: mechanistic insights from integrated multi-omics and single-cell analysis.

ABSTRACT:

Background

Atrial fibrillation (AF) is a complicated and varied cardiovascular disorder with inadequate understanding of its molecular underpinnings. While Programmed cell death factor 4 (PDCD4) has been associated in several illnesses, its particular significance in AF remains unknown. This work seeks to discover PDCD4-associated critical genes and clarify their regulation processes.

Method

We built a protein-protein interaction (PPI) network to emphasize important biological interactions and used transcriptome analysis to find differentially expressed genes (DEGs). Regulatory mechanisms were explored through miRNA-mRNA and transcription factor (TF) analysis. Single-cell RNA sequencing (SCRNA-SEQ) data were utilized to identify crucial cell types and intercellular communica

SUBMITTER: Hailati J 

PROVIDER: S-EPMC12321552 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature