Disease control and disease activity in hereditary angioedema: two sides of the same coin?

ABSTRACT:

Background

Hereditary angioedema (HAE) is a genetic disorder characterized by episodic subcutaneous and submucosal swelling. Patient-reported outcome measures (PROMs) are recommended for routine clinical assessment by international guidelines and are used as secondary outcome measures in pivotal clinical trials for novel investigational drugs. The Angioedema Control Test (AECT) and Hereditary Angioedema Activity Score (HAE-AS) are validated tools designed to aid in HAE patient assessment, but the extent to which they measure different disease outcomes is unclear. The aim of this study was to examine how these measures correlate and inform clinical practice.

Methods

We conducted a retrospective study of patients with HAE types 1 and 2 at the Edmonton Angioedema Center of Refe

SUBMITTER: Heibati B 

PROVIDER: S-EPMC12321560 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature