Closed-loop electrical stimulation prevents focal epilepsy progression and long-term memory impairment.

ABSTRACT: Interictal epileptiform discharges (IEDs) are expressed in epileptic networks and disrupt cognitive functions. It is unclear whether addressing IED-induced dysfunction could improve epilepsy outcomes, as most therapeutic approaches target seizures. We show, in a kindling model of progressive focal epilepsy, that IEDs produce pathological oscillatory coupling associated with prolonged, hypersynchronous neural spiking in synaptically connected cortex and expand the brain territory capable of generating IEDs. A similar relationship between IED-mediated oscillatory coupling and temporal organization of IEDs across brain regions was identified in human participants with refractory focal epilepsy. Spatiotemporally targeted closed-loop electrical stimulation triggered on hippocampal IED occurrenc

SUBMITTER: Ferrero JJ 

PROVIDER: S-EPMC12321579 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature