Dose- and pattern- physical activity is associated with lower risk of dementia.

ABSTRACT:

Background

The amount and pattern of physical activity that benefits cognitive health remain unclear.

Methods

Participants from the UK Biobank cohort who had a full week of accelerometer-based moderate-to-vigorous physical activity (MVPA) and light physical activity (LPA) data were included in the analysis. The data for dementia diagnosis were collected from 2006 to 2024. Associations between the incidence of all-cause dementia, Alzheimer's disease (AD), vascular dementia (VaD), and PA amounts and patterns were assessed using Cox proportional hazards regression models. The analysis included 1) comparing MVPA gradients with reference group performing less than 150 min/week; 2) classifying MVPA patterns as effective intensive (≥300 min/week with ≥50 % of MVPA in 1-2 days), eff

SUBMITTER: Wang Y 

PROVIDER: S-EPMC12321609 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature