Serum BDNF and progression to MCI in cognitively normal older adults: A prospective cohort study.

ABSTRACT:

Background

Brain-derived neurotrophic factor (BDNF) is the most abundant neurotrophin in the mammalian brain. Preclinical studies suggest that BDNF influences the pathophysiology of Alzheimer's disease. In humans, higher blood BDNF levels have been associated with a lower risk of dementia. However, the relationship between serum BDNF levels and the progression to mild cognitive impairment (MCI) in cognitively normal (CN) individuals remains uncertain.

Objectives

To examine whether higher serum BDNF levels in CN older adults are associated with a reduced incidence of MCI over a 4-year follow-up period and to identify potential moderators of this relationship.

Design

Longitudinal analyses were conducted using follow-up data from the Korean Brain Aging Study for Early Di

SUBMITTER: Kim K 

PROVIDER: S-EPMC12321615 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature