Plasma p-tau217 predicting brain-wide tau accumulation in preclinical AD.

ABSTRACT:

Background

Recently developed blood test of Alzheimer's disease (AD) has been recognized as a promising alternative to CSF and PET, as it is noninvasive, cost-effective, and more accessible. Particularly, plasma p-tau217 shows high sensitivity in detecting β-amyloid (Aβ) and tau positivity in early AD. However, the potential value of p-tau217 in revealing Aβ and tau distribution and predicting future development has not been studied.

Objectives

We investigated the dose-response associations between p-tau217 and regional Aβ and tau measured by PET, as well as the longitudinal prediction of p-tau217 for prospective Aβ and tau accumulation measured by longitudinal PET.

Design

Cross-sectional and longitudinal analyses.

Setting

We used data in Anti-Amyloid Treatment

SUBMITTER: Moon H 

PROVIDER: S-EPMC12321616 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature