Multimorbidity and risk of dementia: A systematic review and meta-analysis of longitudinal cohort studies.

ABSTRACT:

Background

Chronic diseases (e.g., hypertension, diabetes, and heart diseases) have been proposed as marked predictors of incident dementia. However, synthesised evidence on the effect of multimorbidity on dementia is still lacking. We aim to summarise the association between multimorbidity and risk of dementia in longitudinal cohorts.

Methods

In this systematic review and meta-analysis, we conducted a systematic search in PubMed, Web of Science and Embase from inception to Dec 14, 2024, to identify longitudinal cohort studies reporting the association between multimorbidity or multimorbidity patterns and risk of dementia. Information of included studies were extracted by three reviewers (YaZ, YY and YuZ), and the quality assessment was conducted using the Newcastle-Ottawa S

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC12321622 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature