Phenotypic alterations in peripheral blood B Lymphocytes of patients with Alzheimer's Disease.

ABSTRACT:

Introduction

Dysfunction of humoral immunity has been implicated in the pathogenesis of Alzheimer's disease (AD). The distribution of B lymphocyte subsets and their clinical relevance in AD remain unclear.

Objective

In this study, we aimed to investigate the distribution of peripheral blood B lymphocyte subsets and their relevance with cognition and biomarkers in AD.

Design, setting, and participants

We evaluated the immunophenotype of peripheral B lymphocytes in 27 AD patients confirmed by PET-Amyloid scan and 32 cognitively normal controls.

Results

The phenotype of B lymphocytes is altered in AD patients. AD patients exhibit a decrease in both the numbers and proportions of switched memory (SwM) B cells and double-negative (DN) B cells. The proportion of unsw

SUBMITTER: Wang MT 

PROVIDER: S-EPMC12321623 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature