Association of multimorbidity and disease clusters with neuroimaging and cognitive outcomes in UK Biobank.

ABSTRACT:

Background

The relationship between multimorbidity, particularly disease clusters, with neuroimaging and cognitive outcomes that typically manifest prior to clinical diagnosis of dementia, remains understudied. This study investigated whether multimorbidity is associated with dementia-related neuroimaging and cognitive outcomes in the UK Biobank cohort.

Methods

This cross-sectional study used data from UK Biobank participants who attended imaging assessments between 2014-2023, and were free from neurological conditions, including dementia. Multimorbidity was defined as the coexistence of two or more long-term conditions, selected from a standardised criteria of 39 conditions. Latent class analyses were used to identify disease clusters. Neuroimaging outcomes were measured us

SUBMITTER: Abid SUA 

PROVIDER: S-EPMC12321637 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature