Lifetime walking and Alzheimer's pathology: A longitudinal study in older adults.

ABSTRACT:

Importance

While many studies have shown that greater amounts or longer durations of walking are associated with a lower risk of Alzheimer's disease (AD) or cognitive decline in older adults, the neuropathological basis for this is not yet fully understood.

Objective

To examine the relationship between walking intensity and duration and longitudinal changes in Alzheimer's disease (AD)-related brain pathologies, including Aβ and tau accumulation, neurodegeneration, and white matter hyperintensity (WMH).

Design

Data were drawn from the Korean Brain Aging Study for the Early Diagnosis and Prediction of AD, a longitudinal cohort study (initiated in 2014).

Setting

Community and memory clinic setting.

Participants

One hundred fifty-one older adults.

Main ou

SUBMITTER: Kim JW 

PROVIDER: S-EPMC12321639 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature