Predictors of celiac disease in patients with type 1 diabetes and positive tissue transglutaminase immunoglobulin A.

ABSTRACT:

Objectives

Identify clinical and serologic features that more accurately predict a diagnosis of celiac disease (CD) in children with type 1 diabetes mellitus (T1DM), particularly focusing on the degree of elevation of tissue transglutaminase immunoglobulin A (TTG IgA) and dilution of positive endomysial antibody (EMA).

Methods

We performed a single-center retrospective review of patients with T1DM who underwent endoscopy from 2016 to 2022 for evaluation of CD. We compared demographic, anthropometric, and laboratory data as well as symptoms and endoscopy findings for subjects with and without CD.

Results

Of 123 subjects who underwent esophagogastroduodenoscopy, 74 (60%) were diagnosed with CD. Univariate logistic regression analysis revealed the factors associated with

SUBMITTER: Rutsky J 

PROVIDER: S-EPMC12321640 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature