Establishment of Coala: a novel 3D and 2D cancer cell line derived from colorectal cancer liver metastasis.

ABSTRACT: Metastatic colorectal cancer is one of the most critical causes of cancer-related dead in patients suffering this type of malignancy. As the liver metastases are found in almost 25-50% of all colorectal cancer patients, there is an urgent need for suitable in vitro and in vivo models. To the best of our knowledge, only a limited number of well-described 2D or 3D organoid/spheroid cell lines originated from human liver metastases was reported for this type of malignancy and submitted to ATCC and other repository centers for general use. Here, we present a novel, well-characterized cell line Coala that was derived directly from liver metastasis of patient with colorectal cancer. Coala cancer cell line was derived by 2D and 3D culture technology and can be, therefore, cultured as standard 2D

SUBMITTER: Mersakova S 

PROVIDER: S-EPMC12321644 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature