Gene expression cluster differences and molecular correlation with the STING pathway in orbital MALT lymphoma and orbital IgG4-related eye disease.

ABSTRACT:

Purpose

Mucosa-associated lymphoid tissue (MALT) lymphoma in the orbital region and IgG4-related ophthalmic disease (IgG4-ROD) account for the majority of mass lesions in the orbital region. These diseases may show similar shadows on radiologic images, and many cases are difficult to differentiate clinically. Using histology, we investigated the gene expression clusters (RNA-seq) and molecular differences responsible for these two diseases.

Design

Retrospective cohort study.

Subjects

Patients diagnosed with orbital MALT and IgG4-ROD who underwent surgical treatment at Osaka Metropolitan University or Kobe Kaisei Hospital, Japan, were included in the study.

Methods

Fresh tissues extracted from 20 cases of MALT lymphoma and IgG4-ROD histopathologically diagnosed

SUBMITTER: Tagami M 

PROVIDER: S-EPMC12321727 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature