Efficacy and safety of different treatments in chemotherapy-induced thrombocytopenia: a systematic review and network meta-analysis.

ABSTRACT:

Background

Chemotherapy-induced thrombocytopenia (CIT) is a challenge in cancer treatment, increasing bleeding risks and reducing chemotherapy dose. We sought to compare the efficacy and safety of various treatments for CIT.

Methods

Randomized controlled trials (RCTs) involving CIT treatments were subjected to a systematic review and network meta-analysis. PubMed, Embase, Web of Science, Cochrane Library, and ClinicalTrials.gov databases were searched up to 2 July 2024.

Results

Sixteen RCTs (n = 1,746) were included in this study. Pairwise meta-analysis showed thrombopoietic agents significantly reduced platelet transfusions (OR = 0.50; 95% CI: 0.32-0.77), improved nadir platelet count (SMD = 0.39; 95% CI: 0.25-0.53) and promoted platelet recovery ≥100 × 10

SUBMITTER: Yang H 

PROVIDER: S-EPMC12321752 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature