Clinical manifestations, diagnostic criteria, and treatment outcomes of minocycline-associated DRESS syndrome: a comprehensive exploration of published cases.

ABSTRACT:

Introduction

Minocycline can induce a rare but serious adverse drug reaction known as drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome. We explored the clinical features of minocycline-associated DRESS to aid in early diagnosis and risk mitigation.

Methods

A comprehensive exploration of published cases from the start of electronic databases (PubMed, Embase, Web of Science, CNKI, Wanfang Data) to December 1, 2024. Cases were screened using RegiSCAR criteria.

Results

A total of 3,928 citations were identified through database searches, and after screening, 39 case reports (comprising 57 patients) were included. Fifty-seven patients (mean age 37.1 years) exhibited median DRESS onset at 17.5 days. Respiratory symptoms (87.7%, n = 50) dominated, inclu

SUBMITTER: Pan Y 

PROVIDER: S-EPMC12321776 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature