Coordinated regulation of timing and strength of synaptic outputs by adrenergic receptors through control of action potentials in Purkinje cells.

ABSTRACT: In contrast to conventional view about the faithful signaling in neuronal axons by all-or-none action potentials, recent studies have shown that axons exhibit dynamic change in action potential waveforms and/or conduction velocities in a manner dependent on neuronal activity and/or inputs to axonal compartments from other neurons. It was recently shown that a well-known second messenger cAMP negatively regulates the axonal voltage-gated Na⁺ channels, which decreases the amplitude and conduction velocity of action potentials in axons of cerebellar Purkinje cells. To understand the signaling mechanism and physiological context of the cAMP-mediated action potential modulation, we studied the involvement of one of neuromodulators, adrenergic system, using direct patch-clamp recordin

SUBMITTER: Furukawa K 

PROVIDER: S-EPMC12321777 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature