Spatiotemporal regulation by downstream genes of <i>Prok2</i> in the olfactory system: from development to function.

ABSTRACT:

Introduction

Olfaction is important for the quality of life; however, in Kallmann syndrome (KS), defective development results in olfactory dysfunction. Notably, the mechanism underlying olfactory development, especially in the olfactory epithelium (OE), which detects olfactory signals, remains unclear. Mutations in PROK2, which encodes prokineticin-2, have been identified in approximately 9% of the KS patients with olfactory defects.

Methods

We examined olfactory function and analyzed the causes of olfactory dysfunction based on spatiotemporal development and gene expression changes in Prok2 knockout (KO) model mice with KS.

Results

The ability of the OE to detect olfactory signals was diminished in adult Prok2 KO mice. Maturation of olfactory sensory n

SUBMITTER: Kim BR 

PROVIDER: S-EPMC12321839 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature