MiR-423-5p and miR-92a-3p in Alzheimer's disease: relationship with pathology and cognition.

ABSTRACT:

Background

MicroRNAs (miRNAs), small and highly conserved non-coding RNA molecules, have emerged as promising molecular biomarkers due to their regulatory roles in gene expression and stability in blood.

Methods

We used measurements of 64 plasma miRNAs from 145 participants in the Alzheimer's disease Neuroimaging Initiative cohort, including 74 probable AD patients and 71 cognitively normal (CN) older adults. We performed principal component analysis (PCA) with factor rotation for dimension reduction to identify AD-associated principal components (PCs) and their key miRNAs with factor loadings higher than 0.8. We investigated their association with amyloid/tau/neurodegeneration (A/T/N) biomarkers and cognition. After identifying the candidate target genes of key miRNAs, we p

SUBMITTER: Han SW 

PROVIDER: S-EPMC12321855 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature