Prediction of risk factors associated with the development of multidrug-resistant tuberculosis in patients with tuberculosis.

ABSTRACT:

Objective

This study aimed to develop and validate a reliable nomogram based on clinical factors to predict development of multidrug-resistant tuberculosis (MDR-TB) associated with individuals with tuberculosis (TB), so as to reduce the harm and economic burden caused by disease progression.

Methods

The study included 4,251 individuals with TB who received treatment at Huzhou Central Hospital between January 2016 and December 2023, excluding 87 individuals because of infection with non-TB mycobacterium or incomplete information (including missing laboratory or clinical data). A total of 4,164 individuals (2,261 sputum smear-positive and 1,903 sputum smear-negative patients) were ultimately included in the analysis. This analysis incorporated clinical baseline presentations,

SUBMITTER: Chen H 

PROVIDER: S-EPMC12321860 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature