Unveiling the Relationship Between Oral Microbiota and Alzheimer's Disease: A Genetic Instrumental Variable Analysis via Mendelian Randomization.

ABSTRACT:

Background

The potential relationship between oral microbiota (OM) and Alzheimer's disease (AD) is increasingly recognized, but the exact causal relationship between them remains uncertain. This study aims to reveal the causal relationship between OM and AD.

Methods

A two-sample Mendelian randomization (MR) approach was employed to examine the association between 594 OM exposures and AD outcomes. Effect estimates were derived from external genome-wide association study (GWAS) summary statistics, primarily utilizing inverse-variance weighted (IVW) analysis. Sensitivity analyses were conducted to assess the robustness of the findings. In addition, we genetically mapped SNPs corresponding to OM in the MR analysis to identify genes that may link OM to AD.

Results

A total

SUBMITTER: Li Z 

PROVIDER: S-EPMC12321961 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature