Exploring the Causal Relationship Between Inflammatory Bowel Disease and Bell's Palsy Based on Inflammatory Proteins: A Mendelian Randomization Study.

ABSTRACT:

Background

The relationship between inflammatory bowel disease (IBD) and Bell's palsy remains unsubstantiated. This study aims to investigate the causal relationship between IBD and Bell's palsy.

Methods

Using the two-sample Mendelian randomization (MR) method to explore the relationship between IBD and Bell's palsy. We applied Bell's palsy summary statistics from GWAS statistics for 91 inflammatory proteins and FinnGen R10 and IBD summary statistics from the International Inflammatory Bowel Disease Genetics Consortium.

Results

The two-sample MR study indicates a significant positive association between IBD and Bell's palsy (OR: 1.13, 95% CI [1.03-1.23], p = 0.0065) and between Crohn's disease and Bell's palsy (OR: 1.10, 95% CI [1.02-1.18], p = 0.0088). After applying

SUBMITTER: Fan D 

PROVIDER: S-EPMC12321965 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature