Association Between Trajectories of Depressive Symptoms and Cardiovascular Disease in Elderly Chinese Adults: Findings From the China Health and Retirement Longitudinal Study (CHARLS).

ABSTRACT:

Background

Although the association between depressive symptoms and cardiovascular disease (CVD) has been widely investigated, most existing studies have relied on single-timepoint assessments of depression. Examining longitudinal trajectories of depressive symptoms may provide deeper insights into the dynamic and complex relationship between depression and CVD risk.

Methods

Based on data from the China Health and Retirement Longitudinal Study (CHARLS), this study analyzed the relationship between depressive symptom trajectories and CVD risk through logistic regression modeling and latent category growth modeling (LCGM) and explored causality using two-sample Mendelian randomisation (MR).

Results

The study found four depressive symptom trajectories among Chinese older

SUBMITTER: Wang D 

PROVIDER: S-EPMC12321971 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature