Combining mucosal microbiome and host multi-omics data shows prognostic potential in paediatric ulcerative colitis.

ABSTRACT: Current first-line treatments of paediatric ulcerative colitis (UC) maintain a 6-month remission in only half of the patients. Relapse prediction at diagnosis could enable earlier introduction of immunosuppressants. We collected intestinal biopsies from 56 treatment-naïve children, combining mucosal quantitative microbial profiling with host epigenomics, transcriptomics, genotyping, and in vitro and in vivo experiments on selected bacteria. Baseline bacterial diversity is lower in relapsing children, who have fewer butyrate producers but more oral-associated bacteria, whereof Veillonella parvula induces inflammation in epithelial cell lines and IL10^-/- mice. Microbiota has the strongest association with future relapse, followed by host epigenome and transcriptome. Interferon gam

SUBMITTER: Kulecka M 

PROVIDER: S-EPMC12322004 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature