Pirfenidone combined with UC-MSCs reversed bleomycin-induced pulmonary fibrosis.

ABSTRACT: Pulmonary fibrosis (PF) is a progressive, irreversible disease with limited effective treatments. Human umbilical cord-derived mesenchymal stem cells (UC-MSCs) have recently shown promise in PF therapy. This study evaluated the therapeutic effects and mechanisms of UC-MSCs combined with pirfenidone (PFD) in a bleomycin-induced PF model. C57BL/6 mice were divided into nine groups: control, model, PFD (100 mg/kg), UC-MSCs (0.5 × 10⁶, 1.0 × 10⁶, and 2.0 × 10⁶ cells per animal), and PFD (100 mg/kg) + UC-MSCs (0.5 × 10⁶, 1.0 × 10⁶, and 2.0 × 10⁶ cells per animal). The model was established by intratracheal bleomycin instillation. PFD was administered intraperitoneally twice daily from day 4 to 21 in the PFD and PFD + UC-MSCs grou

SUBMITTER: Xu J 

PROVIDER: S-EPMC12322009 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature