Non-linear relationship between serum iron levels and 28-day mortality in sepsis patients: a retrospective study.

ABSTRACT: Recent studies have shown a significant association between iron and the development and prognosis of sepsis, but the relationship between iron levels and mortality in sepsis patients remains unclear, with previous studies examining this relationship under a linear assumption. This retrospective observational study aimed to assess the possible non-linear relationship between serum iron (SI) levels and 28-day all-cause mortality (28-DACM) in individuals with sepsis. We used multiple imputation for data with less than 30% missing values and developed Cox models to calculate the hazard ratio (HR) with a 95% confidence interval (CI) for the main outcome (28-DACM). To accurately assess the relationship between SI levels and the HR for 28-DACM, we utilized a restricted cubic spline (RCS) regress

SUBMITTER: Jin J 

PROVIDER: S-EPMC12322023 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature