"I'm quite proud of how we've handled it": health professionals' experiences of returning additional findings from the 100,000 genomes project.

ABSTRACT: Participants in the 100,000 Genomes Project (100kGP) could consent to receive additional finding (AF) results, individual variants relating to genes associated with susceptibility to cancer and familial hypercholesterolemia (FH). In the study reported here, qualitative interviews were used to explore the experiences of National Health Service (NHS) professionals from across England who were tasked with returning over 80,000 "no AF" results and 700 positive AF results to 100kGP participants. Interviews were conducted with 45 professionals from a range of backgrounds, including Genetic Counsellors, Clinical Geneticists, FH Clinical Nurse Specialists and Clinical Scientists. Interviews were analysed using a codebook thematic analysis approach. Returning AF results has been a significant endea

SUBMITTER: Stafford-Smith B 

PROVIDER: S-EPMC12322091 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature