Multi-omics prediction of axillary treatment response and tumour microenvironment alterations in lymph node-positive luminal breast cancer.

ABSTRACT: Luminal breast cancer (BC) with axillary lymph node (ALN) metastasis is typically treated with neoadjuvant chemotherapy (NAC). Theoretically, patients who achieve pathological lymph node complete response after NAC can be exempted from ALN dissection and even have the possibility of being spared axillary surgery. However, there is no effective way to preoperatively assess whether a metastatic ALN achieved pathological lymph node complete response (pLCR) after NAC. Therefore, we retrospectively collected imaging, clinical, and pathological data from two centres, built a multi-omic model to predict pLCR, and validated its accuracy and clinical applicability. We identified 12 radiomic and four clinicopathological features for model construction; the areas under the curve for training and vali

SUBMITTER: Ma T 

PROVIDER: S-EPMC12322124 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature