Smooth muscle cell-specific deletion of TXNIP ameliorates medial vascular calcification.

ABSTRACT: Vascular calcification is an important pathological characteristic of cardiovascular diseases, often exacerbated by metabolic disorders such as chronic kidney disease and diabetes mellitus. Recent studies have highlighted oxidative stress and inflammation as central mechanisms in the development of vascular calcification. While TXNIP is known to positively regulate reactive oxygen species generation and inflammasome activation, the specific contributions of TXNIP to vascular calcification have not been thoroughly elucidated. Here we aimed to elucidate the role of TXNIP in the pathogenesis of vascular calcification through combined in vitro and in vivo approaches. Medial calcification was evaluated by murine models of a 5/6 nephrectomy mouse model and a vitamin D3-induced mouse model with n

SUBMITTER: Hwang AR 

PROVIDER: S-EPMC12322165 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature