A Mendelian randomization study of the gut microbiota and risk of knee osteoarthritis and the mediating role of immune cells.

ABSTRACT: With increasing research on the gut microbiota (GM), there is growing evidence suggesting that GM may influence the risk of knee osteoarthritis (KOA) by modulating immune cell activity. However, the causal relationship between GM, immune cells, and KOA has not been thoroughly investigated. This study aimed to investigate the causal effect of GM on KOA and to identify immune cell mechanisms that may play a mediating role. A bidirectional two-sample univariable Mendelian randomization (UVMR) analysis was conducted to assess the association between GM and KOA. Additionally, mediation analyses were performed to identify critical mediators in the association between GM and KOA, assessing the causal relationship between the two conditions and potential immune cell mediators. UVMR analyses reveal

SUBMITTER: Zhang J 

PROVIDER: S-EPMC12322212 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature