Dynamics of chromatin accessibility governing Gd-IgA1 synthesis in B cells associated with IgA nephropathy.

ABSTRACT: IgA nephropathy (IgAN) is the most common primary glomerulonephritis worldwide. B cells are believed to play a central role in the pathogenesis of IgAN by producing galactose-deficient IgA1 (Gd-IgA1), partly due to aberrant gene expression in B cells. However, the mechanisms underlying the abnormal gene expression in B cells derived from patients with IgAN remain elusive. Here we unveil a broad spectrum of variations in chromatin accessibility in B cells of patients with IgAN through an assay for transposase-accessible chromatin using sequencing (ATAC-seq) by evaluating active DNA regulatory components. A total of 629 genes showed transcriptional alterations associated with differentially chromatin accessibility. The degree of chromatin accessibility was associated with gene expression in

SUBMITTER: Gan Y 

PROVIDER: S-EPMC12322228 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature