Compensatory cerebellar activation during fluid intelligence processing following mild traumatic brain injury.

ABSTRACT: Cognitive outcome following mild traumatic brain injury (mTBI) vary widely, with many individuals experiencing long-term impairments associated with frontoparietal network dysfunction. Mild TBI patients have demonstrated functional reorganization, suggesting an expansion of activation to cerebellar regions during specific executive functions. In this study, we investigated cerebellar involvement in fluid intelligence processing using a novel fMRI paradigm based on Raven's Progressive Matrices in 51 acute mTBI patients and 61 healthy controls. Despite comparable task accuracy, mTBI patients exhibited significantly increased activation in anterior cerebellar regions, including Vermis III and Cerebellum IV-V. Seed-based functional connectivity analysis further revealed altered cerebellar-fron

SUBMITTER: Leibovici A 

PROVIDER: S-EPMC12322230 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature