Quadruple-refocused spin-locking: A robust method for high-amplitude T_1ρ imaging.

ABSTRACT:

Purpose

Longitudinal relaxation time in the rotating frame (T_1ρ) is a source of tissue-specific contrasts, with applications in detecting myocardial fibrosis, liver fibrosis, and early-stage osteoarthritis. However, T_1ρ measurements are sensitive to static (B₀) and radiofrequency (B₁) magnetic field inhomogeneities. Improving the accuracy of T_1ρ quantification can enable earlier and more reliable detection of pathological changes, providing a basis for early intervention. Therefore, we have developed an improved, quadruple-refocused spin-locking (QR-SL) technique based on existing preparation schemes to obtain a more robust compensation for B₀ and B₁ field inhomogeneities.

Methods

The QR-SL module c

SUBMITTER: Wan C 

PROVIDER: S-EPMC12322236 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature