Anticancer activity of triterpene glycosides from the sea star Solaster pacificus.

ABSTRACT: Marine triterpene glycosides are known to exhibit significant anticancer activity. We investigated pacificusoside C and cucumariosides C₁ and C₂ isolated from a sea star Solaster pacificus in prostate cancer models with varying drug resistance and in non-cancerous cells in vitro. Cucumarioside C₁ showed selectivity comparable to cisplatin, whereas the other compounds were less selective. Cucumarioside C₁ induced apoptosis and enhanced cytotoxic effects of cisplatin, carboplatin, docetaxel, and cabazitaxel, making it a potential candidate for combination therapy. All three glycosides were active in docetaxel-resistant cells and were neither inhibitors nor substrates of P-glycoprotein, indicating P-glycoprotein-independent activity. To explore the

SUBMITTER: Dyshlovoy SA 

PROVIDER: S-EPMC12322260 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature